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An AI Tool to Make Clinical Trials More Inclusive
Article

An AI Tool to Make Clinical Trials More Inclusive

An artificial-intelligence tool called Trial Pathfinder can run clinical-trial emulations using healthcare data from people with cancer, and can learn how to optimize trial-inclusion eligibility criteria, while maintaining patient safety.

Nature, 2021
References: Liu et al. (2021)


Editorial Rating

8

Qualities

  • Analytical
  • Scientific
  • Engaging

Recommendation

The AI software Trial Pathfinder offers hope for medical clinicians looking to safely expand and diversify clinical drug trials, for cancer and other diseases. Chunhua Weng and James Rogers outline a Stanford University research project, led by Ruishan Liu, which revealed the possibility of including people in trials who have often been excluded for reasons of age, health or gender. 

Take-Aways

  • Clinical trial success often depends on enrolling people who meet study criteria within a specific time period.
  • Ruishan Liu’s team created an open-source AI tool dubbed Trial Pathfinder.
  • Liu’s team identified restrictive, non-beneficial criteria when they analyzed clinical trials for other cancer types.

About the Authors

Chunhua Weng and James R. Rogers are members of the Department of Biomedical Informatics at Columbia University.


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