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The World’s First Virus-Proof Cell, with Redesigned DNA, Is About to Meet the Test of Its Life
Article

The World’s First Virus-Proof Cell, with Redesigned DNA, Is About to Meet the Test of Its Life

Biologists are building an organism that can shrug off any virus on the planet. Impervious human cells may be next

Scientific American, 2019 more...


Editorial Rating

9

Qualities

  • Innovative
  • Scientific
  • Eye Opening

Recommendation

Genetic engineers are working on a bacterial cell that can thwart all viruses. They removed a key component of the cell’s protein-making apparatus required by both the bacterial host and the viral invader. The bacteria are fine, but any virus that gets in won’t find the tools it needs for infection. When a virus tries to infect, it simply gets stuck. These reprogrammed cells should be a boon for medical research and drug development. The article will inspire anyone interested in directed evolution and synthetic biology.

Take-Aways

  • Viruses exploit the genetic code, commandeering cellular machinery to make copies of themselves.
  • Researchers are making a bacterial cell impervious to viruses by replacing code redundant to the bacteria but still essential to viruses.
  • This reprogrammed cell may be a useful tool for drug development and biomedical research.

About the Author

Rowan Jacobsen is a journalist and author of several books, such as Shadows on the Gulf and Truffle Hound. His many magazine articles include “The Invulnerable Cell” in Scientific American’s July 2019 issue [identical with this article] and “Ghost Flowers,” published in February of that year. He was a 2017–2018 Knight Science Journalism Fellow at the Massachusetts Institute of Technology.


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